Slope Factors (SF) for Carcinogens from US EPA

View Slope Factors from: Health Canada | US EPA


Chemical Name


CAS Number
Oral slope factor
(1/mg/kg/d)
Inhalation slope factor
(1/mg/kg/d)

Volatile Organic Compound
(VOC)?
ACETALDEHYDE 75070 0.0077 I y
ACETOCHLOR
34256821




ACETONE
67641



y
ACETONITRILE 75058 y
ACETOPHENONE
98862



y
ACROLEIN
107028



y
ACRYLAMIDE 79061 4.5 I 4.5 I
ACRYLONITRILE
107131 0.54 I 0.24 I y
ALACHLOR
15972608 0.08 H


ALAR 1596845
ALDICARB
116063




ALDICARB SULFONE
1646884




ALDRIN 309002 17 I 17 I
**ALUMINUM
7429905




AMINODINITROTOLUENES





AMMONIA 7664417 y
ANILINE
62533 0.0057 I


ANTIMONY
7440360




ANTIMONY TRIOXIDE 1309644
ARSENIC
7440382 1.5 I 15.1 I
ARSINE
7784421



y
ASSURE 76578148
ATRAZINE
1912249 0.22 H


BARIUM
7440393




BAYGON 114261
BAYTHROID
68359375




BENTAZON
25057890




BENZALDEHYDE 100527
BENZENE
71432 0.055 I 0.027 I y
BENZENETHIOL
108985



y
BENZIDINE m 92875 230 I 230 I
BENZOIC ACID
65850




BENZYL ALCOHOL
100516




BENZYL CHLORIDE 100447 0.17 I y
BERYLLIUM
7440417

8.4 I
BIPHENYL
92524



y
BIS(2-CHLOROETHYL)ETHER 111444 1.1 I 1.1 I y
BIS(2-CHLOROISOPROPYL)ETHER
108601 0.07 H 0.035 H y
BIS(CHLOROMETHYL)ETHER
542881 220 I 220 I y
BIS(2-ETHYLHEXYL)PHTHALATE 117817 0.014 I
BORON
7440428




BROMODICHLOROMETHANE
75274 0.062 I

y
BROMOETHENE 593602 0.11 H y
BROMOFORM
75252 0.0079 I 0.0039 I
BROMOMETHANE
74839



y
BROMOPHOS 2104963
1,3-BUTADIENE
106990

0.1 I y
1-BUTANOL
71363




BUTYLBENZYLPHTHALATE 85687
CADMIUM-WATER
7440439

6.3 I
CADMIUM-FOOD
7440439

6.3 I
CAPROLACTAM 105602
CARBARYL
63252




CARBON DISULFIDE
75150



y
CARBON TETRACHLORIDE 56235 0.13 I 0.053 I y
CARBOSULFAN
55285148




CHLORAL HYDRATE
302170




CHLORANIL 118752 0.4 H
CHLORDANE
57749 0.35 I 0.35 I
CHLORINE DIOXIDE
10049044



y
CHLOROACETIC ACID 79118
4-CHLOROANILINE
106478




CHLOROBENZENE
108907



y
2-CHLORO-1,3-BUTADIENE 126998 y
1-CHLORO-1,1-DIFLUOROETHANE
75683



y
CHLORODIFLUOROMETHANE
75456



y
CHLOROETHANE 75003 0.0029 E y
CHLOROFORM
67663

0.081 I y
CHLOROMETHANE
74873



y
4-CHLORO-2-METHYLANILINE 95692 0.58 H
BETA-CHLORONAPHTHALENE
91587



y
2-CHLOROPHENOL
95578



y
2-CHLOROPROPANE 75296 y
O-CHLOROTOLUENE
95498



y
P-CHLOROTOLUENE
106434



y
CHLORPYRIFOS 2921882
CHLORPYRIFOS-METHYL
5598130




CHROMIUM III
16065831




CHROMIUM VI 18540299 41 I
COKE OVEN EMISSIONS (COAL TAR) m 8007452

2.2 I
COPPER
7440508




CUMENE 98828 y
CYANIDE (FREE)
57125




CALCIUM CYANIDE
592018




COPPER CYANIDE 544923
CYANOGEN
460195



y
HYDROGEN CYANIDE
74908



y
POTASSIUM CYANIDE 151508
POTASSIUM SILVER CYANIDE
506616




SILVER CYANIDE
506649




SODIUM CYANIDE 143339
THIOCYANATES





ZINC CYANIDE
557211




CYCLOHEXANE 110827 y
CYCLOHEXANONE
108941




CYHALOTHRIN/KARATE
68085858




CYPERMETHRIN 52315078
DACTHAL
1861321




DALAPON
75990




DDD 72548 0.24 I
DDE
72559 0.34 I


DDT
50293 0.34 I 0.34 I
DIAZINON 333415
**DIBENZOFURAN
132649




1,4-DIBROMOBENZENE
106376




DIBROMOCHLOROMETHANE 124481 0.084 I y
1,2-DIBROMO-3-CHLOROPROPANE m 96128 0.8 P 21 P y
1,2-DIBROMOETHANE
106934 2 I 2 I y
DIBUTYLPHTHALATE 84742
DICAMBA
1918009




1,2-DICHLOROBENZENE
95501



y
1,3-DICHLOROBENZENE 541731 y
1,4-DICHLOROBENZENE
106467 0.024 H 0.022 E y
3,3'-DICHLOROBENZIDINE
91941 0.45 I


DICHLORODIFLUOROMETHANE 75718 y
1,1-DICHLOROETHANE
75343



y
1,2-DICHLOROETHANE
107062 0.091 I 0.091 I y
1,1-DICHLOROETHENE 75354 y
CIS-1,2-DICHLOROETHENE
156592



y
**TRANS-1,2-DICHLOROETHENE
156605



y
TOTAL 1,2-DICHLOROETHENE 540590 y
2,4-DICHLOROPHENOL
120832




2,4-D
94757




4-(2,4-DICHLOROPHENOXY)BUTYRIC ACID 94826
1,2-DICHLOROPROPANE
78875 0.068 H

y
1,3-DICHLOROPROPANE
142289



y
2,3-DICHLOROPROPANOL 616239
1,3-DICHLOROPROPENE
542756 0.1 I 0.01 I y
DICHLORVOS
62737 0.29 I

DIELDRIN 60571 16 I 16 I
DIESEL EMISSIONS




DIETHYLPHTHALATE
84662



DI(2-ETHYLHEXYL)ADIPATE 103231 0.0012 I
DIETHYLSTILBESTROL
56531 4700 H

DIFENZOQUAT (AVENGE)
43222486



1,1-DIFLUOROETHANE 75376 y
DIISOPROPYL METHYLPHOSPHONATE (DIMP)
1445756



3,3'-DIMETHOXYBENZIDINE
119904 0.014 H

N,N-DIMETHYLANILINE 121697
2,4-DIMETHYLPHENOL
105679



2,6-DIMETHYLPHENOL
576261



3,4-DIMETHYLPHENOL 95658
1,2-DINITROBENZENE
528290



1,3-DINITROBENZENE
99650



1,4-DINITROBENZENE 100254
4,6-DINITRO-O-CYCLOHEXYL PHENOL
131895



2,4-DINITROPHENOL
51285



DINITROTOLUENE MIX 0.68 I
2,4-DINITROTOLUENE
121142



2,6-DINITROTOLUENE
606202



DINOSEB 88857
1,4-DIOXANE
123911 0.011 I

DIPHENYLAMINE
122394



1,2-DIPHENYLHYDRAZINE 122667 0.8 I 0.8 I
DIQUAT
85007



DISULFOTON
298044



1,4-DITHIANE 505293
DIURON
330541



ENDOSULFAN
115297



ENDRIN 72208
EPICHLOROHYDRIN
106898 0.0099 I 0.0042 I y
ETHION
563122



ETHYL ACETATE 141786 y
ETHYLBENZENE
100414



y
ETHYLENE GLYCOL
107211



ETHYLENE GLYCOL, MONOBUTYL ETHER 111762
ETHYLENE OXIDE
75218 1 H 0.35 H y
ETHYL ETHER
60297



y
FENAMIPHOS 22224926
FLUOMETURON
2164172



FLUORINE
7782414



FOMESAFEN 72178020 0.19 I
FONOFOS
944229



FORMALDEHYDE
50000

0.045 I
FURAN 110009 y
FURFURAL
98011



GLYPHOSATE
1071836



HEPTACHLOR 76448 4.5 I 4.5 I
HEPTACHLOR EPOXIDE
1024573 9.1 I 9.1 I
HEXABROMOBENZENE
87821



HEXACHLOROBENZENE 118741 1.6 I 1.6 I
HEXACHLOROBUTADIENE
87683 0.078 I 0.078 I
ALPHA-HCH
319846 6.3 I 6.3 I
BETA-HCH 319857 1.8 I 1.8 I
GAMMA-HCH (LINDANE)
58899 1.3 H

TECHNICAL HCH
608731 1.8 I 1.8 I
HEXACHLOROCYCLOPENTADIENE 77474
HEXACHLORODIBENZODIOXIN MIX
19408743 6200 I 4550 I
HEXACHLOROETHANE
67721 0.014 I 0.014 I
HEXACHLOROPHENE 70304
1,6-HEXAMETHYLENE DIISOCYANATE
822060



HEXANE
110543



y
HMX 2691410
HYDRAZINE
302012 3 I 17 I
HYDROGEN CHLORIDE
7647010



HYDROGEN SULFIDE 7783064
**IRON
7439896



ISOBUTANOL
78831



y
ISOPHORONE 78591 0.00095 I
TETRAETHYLLEAD
78002



KEPONE
143500



LITHIUM 7439932
MALATHION
121755



MALEIC ANHYDRIDE
108316



MANGANESE-NONFOOD 7439965
MANGANESE-FOOD
7439965



MEPHOSFOLAN
950107



MEPIQUAT CHLORIDE 24307264
MERCURIC CHLORIDE
7487947



MERCURY (elemental)
7439976



METHYLMERCURY 22967926
METHANOL
67561



METHIDATHION
950378



METHOXYCHLOR 72435
METHYL ACETATE
79209



y
METHYL ACRYLATE
96333



y
2-METHYLANILINE 95534 0.24 H
4-(2-METHYL-4-CHLOROPHENOXY) BUTYRIC ACID
94815



2-METHYL-4-CHLOROPHENOXYACETIC ACID (MCPA)
94746



2-(2-METHYL-4-CHLOROPHENOXY)PROPIONIC ACID (MCPP) 93652
METHYLCYCLOHEXANE
108872



y
METHYLENE BROMIDE
74953



y
METHYLENE CHLORIDE 75092 0.0075 I 0.00165 I y
4,4'-METHYLENE BIS(2-CHLOROANILINE) m 101144 0.1 P 0.13 H
4,4'-METHYLENE BIS(N,N'-DIMETHYL)ANILINE
101611 0.046 I

4,4'-METHYLENEDIPHENYL ISOCYANATE 101688
METHYL ETHYL KETONE (2-BUTANONE)
78933



y
METHYL ISOBUTYL KETONE (4-METHYL-2-PENTANONE)
108101



y
METHYL METHACRYLATE 80626 y
METHYL PARATHION
298000



2-METHYLPHENOL
95487



3-METHYLPHENOL 108394
4-METHYLPHENOL
106445



METHYLSTYRENE MIX
25013154



y
ALPHA-METHYLSTYRENE 98839 y
METHYL TERT-BUTYL ETHER
1634044 0.004 O

y
METOLACHLOR (DUAL)
51218452



MIREX 2385855
MOLYBDENUM
7439987



MONOCHLORAMINE
10599903



NALED 300765
NICKEL REFINERY DUST


0.84 I
NICKEL
7440020




NITRATE 14797558
NITRITE
14797650




NITROBENZENE
98953



y
**NITROGLYCERIN 55630 0.017 P
2-NITROPROPANE
79469

9.4 H y
N-NITROSO-DI-N-BUTYLAMINE
924163 5.4 I 5.6 I y
N-NITROSODIETHANOLAMINE 1116547 2.8 I
**N-NITROSODIETHYLAMINE m 55185 150 I 150 I
**N-NITROSODIMETHYLAMINE m 62759 51 I 51 I
N-NITROSODIPHENYLAMINE 86306 0.0049 I
N-NITROSODIPROPYLAMINE
621647 7 I


N-NITROSO-N-METHYLETHYLAMINE
10595956 22 I


N-NITROSOPYRROLIDINE 930552 2.1 I 2.1 I
O-NITROTOLUENE
88722



y
NUSTAR
85509199




ORYZALIN 19044883
OXADIAZON
19666309




OXAMYL
23135220




OXYFLUORFEN 42874033
PARAQUAT DICHLORIDE
1910425




PARATHION
56382




PENTACHLOROBENZENE 608935
PENTACHLORONITROBENZENE
82688 0.26 H


PENTACHLOROPHENOL
87865 0.12 I


PERCHLORATE
PERMETHRIN
52645531




PHENOL
108952




M-PHENYLENEDIAMINE 108452
O-PHENYLENEDIAMINE
95545 0.047 H


P-PHENYLENEDIAMINE
106503




PHOSGENE 75445 y
PHOSPHINE
7803512




PHOSPHORIC ACID
7664382




PHOSPHORUS (WHITE) 7723140
PHTHALIC ANHYDRIDE
85449




POLYBROMINATED BIPHENYLS
8.9 H


POLYCHLORINATED BIPHENYLS 1336363 2 I 2 I
AROCLOR-1016
12674112 0.07 I 0.07 I
AROCLOR-1221
11104282 2 I 2 I
AROCLOR-1232 11141165 2 I 2 I
AROCLOR-1242
53469219 2 I 2 I
AROCLOR-1248
12672296 2 I 2 I
AROCLOR-1254 11097691 2 I 2 I
AROCLOR-1260
11096825 2 I 2 I
POLYNUCLEAR AROMATIC HYDROCARBONS:





ACENAPHTHENE 83329 y
ANTHRACENE
120127



y
BENZ[A]ANTHRACENE m 56553 0.73 E


BENZO[B]FLUORANTHENE m 205992 0.73 E
BENZO[K]FLUORANTHENE m 207089 0.073 E


BENZO[A]PYRENE m 50328 7.3 I 3.1 E
CARBAZOLE 86748 0.02 H
CHRYSENE m 218019 0.0073 E


DIBENZ[A,H]ANTHRACENE m 53703 7.3 E


FLUORANTHENE 206440
FLUORENE
86737



y
INDENO[1,2,3-C,D]PYRENE m 193395 0.73 E


2-METHYLNAPHTHALENE 91576 y
NAPHTHALENE
91203



y
PYRENE
129000



y
PROMETON 1610180
PROMETRYN
7287196




PROPACHLOR
1918167




PROPARGITE 2312358
PROPYLENE GLYCOL, MONOETHYL ETHER
52125538




PROPYLENE GLYCOL, MONOMETHYL ETHER
107982




PURSUIT 81335775
PYRIDINE
110861




QUINOLINE
91225 3 I


RDX 121824 0.11 I
RESMETHRIN
10453868




ROTENONE
83794




SELENIUM 7782492
SILVER
7440224




SIMAZINE
122349 0.12 H


SODIUM DIETHYLDITHIOCARBAMATE 148185 0.27 H
STRONTIUM, STABLE
7440246




STRYCHNINE
57249




STYRENE 100425 y
2,3,7,8-TETRACHLORODIBENZODIOXIN
1746016 150000 H 150000 H
1,2,4,5-TETRACHLOROBENZENE
95943




1,1,1,2-TETRACHLOROETHANE 630206 0.026 I 0.026 I y
**1,1,2,2-TETRACHLOROETHANE
79345 0.2 I 0.2 I y
TETRACHLOROETHENE
127184 0.54 O 0.02 O y
2,3,4,6-TETRACHLOROPHENOL 58902
P,A,A,A-TETRACHLOROTOLUENE
5216251 20 H


1,1,1,2-TETRAFLUOROETHANE
811972



y
TETRAHYDROFURAN 109999 0.0076 E 0.0068 E
TETRYL
479458




THALLIUM
7440280




THALLIUM ACETATE 563688
THALLIUM CARBONATE
6533739




THALLIUM CHLORIDE
7791120




THALLIUM NITRATE 10102451
THALLIUM SULFATE (2:1)
7446186




THIOBENCARB
28249776




TIN 7440315
TOLUENE
108883



y
TOLUENE-2,4-DIAMINE
95807 3.2 H


TOLUENE-2,5-DIAMINE 95705
TOLUENE-2,6-DIAMINE
823405




P-TOLUIDINE
106490 0.19 H


TOXAPHENE 8001352 1.1 I 1.1 I
1,2,4-TRIBROMOBENZENE
615543




TRIBUTYLTIN OXIDE
56359




2,4,6-TRICHLOROANILINE 634935 0.034 H
1,2,4-TRICHLOROBENZENE
120821



y
1,1,1-TRICHLOROETHANE
71556



y
1,1,2-TRICHLOROETHANE 79005 0.057 I 0.056 I y
TRICHLOROETHENE
79016 0.4 E 0.4 E y
TRICHLOROFLUOROMETHANE
75694



y
2,4,5-TRICHLOROPHENOL 95954
2,4,6-TRICHLOROPHENOL
88062 0.011 I 0.01 I
2,4,5-T
93765




2-(2,4,5-TRICHLOROPHENOXY)PROPIONIC ACID 93721
1,1,2-TRICHLOROPROPANE
598776



y
1,2,3-TRICHLOROPROPANE
96184 2 E

y
1,1,2-TRICHLORO-1,2,2-TRIFLUOROETHANE 76131 y
1,3,5-TRINITROBENZENE
99354




2,4,6-TRINITROTOLUENE
118967 0.03 I


URANIUM (SOLUBLE SALTS; from IRIS) 7440611
URANIUM (SOLUBLE SALTS; provisional)
7440611




VANADIUM
7440622




VINCLOZOLIN 50471448
VINYL ACETATE
108054



y
VINYL CHLORIDE inc earlylife(see cover memos)
75014 1.4 I 0.03 I y
VINYL CHLORIDE: adult (see cover memos) 75014 0.72 I 0.015 I y
WARFARIN
81812




XYLENES
1330207



y
ZINC 7440666
ZINEB
12122677






Table Sources:
I = IRIS
H = HEAST
A = HEAST Alternate
M = ATSDR MRL (chronic)
E = EPA-NCEA provisional value
O = other
P = EPA provisional peer-reviewed value
m = Default ADAFs applied, carcinogenic via mutagenic mode of action
Adapted from US EPA region III (2007); http://www.epa.gov/reg3hwmd/risk/human/index.htm 

 
Hatfield Consultants The World Bank funded by the Canadian POPs Trust Fund through the      
Canadian International Development Agency