Non-Carcinogen Tolerable Daily Intake (TDI) Values from US EPA

View TDI Values from: Health Canada | US EPA


Chemical Name

CAS Number		 TDI oral
(mg/kg-d)
TDI inhalation
(mg/kg-d)

Volatile Organic Compound
(VOC)?
ACETALDEHYDE 75070 0.00257 I y
ACETOCHLOR
34256821 0.02 I


ACETONE
67641 0.9 I

y
ACETONITRILE 75058 0.017 I y
ACETOPHENONE
98862 0.1 I

y
ACROLEIN
107028 0.0005 I 0.0000057 I y
ACRYLAMIDE 79061 0.0002 I
ACRYLONITRILE
107131 0.001 H 0.00057 I y
ALACHLOR
15972608 0.01 I


ALAR 1596845 0.15 I
ALDICARB
116063 0.001 I


ALDICARB SULFONE
1646884 0.001 I


ALDRIN 309002 0.00003 I
**ALUMINUM
7429905 1 P 0.001 P
AMINODINITROTOLUENES
0.002 E


AMMONIA 7664417 0.0286 I y
ANILINE
62533 0.007 P 0.00029 I
ANTIMONY
7440360 0.0004 I


ANTIMONY TRIOXIDE 1309644 0.0004 H 0.000057 I
ARSENIC
7440382 0.0003 I


ARSINE
7784421
0.000014 I y
ASSURE 76578148 0.009 I
ATRAZINE
1912249 0.035 I


BARIUM
7440393 0.2 I 0.00014 A
BAYGON 114261 0.004 I
BAYTHROID
68359375 0.025 I


BENTAZON
25057890 0.03 I


BENZALDEHYDE 100527 0.1 I
BENZENE
71432 0.004 I 0.0086 I y
BENZENETHIOL
108985 0.00001 H

y
BENZIDINE m 92875 0.003 I
BENZOIC ACID
65850 4 I


BENZYL ALCOHOL
100516 0.5 P


BENZYL CHLORIDE 100447 y
BERYLLIUM
7440417 0.002 I 0.0000057 I
BIPHENYL
92524 0.05 I

y
BIS(2-CHLOROETHYL)ETHER 111444 y
BIS(2-CHLOROISOPROPYL)ETHER
108601 0.04 I

y
BIS(CHLOROMETHYL)ETHER
542881


y
BIS(2-ETHYLHEXYL)PHTHALATE 117817 0.02 I
BORON
7440428 0.2 I 0.0057 H
BROMODICHLOROMETHANE
75274 0.02 I

y
BROMOETHENE 593602 0.00086 I y
BROMOFORM
75252 0.02 I


BROMOMETHANE
74839 0.0014 I 0.0014 I y
BROMOPHOS 2104963 0.005 H
1,3-BUTADIENE
106990
0.00057 I y
1-BUTANOL
71363 0.1 I


BUTYLBENZYLPHTHALATE 85687 0.2 I
CADMIUM-WATER
7440439 0.0005 I 0.000057 E
CADMIUM-FOOD
7440439 0.001 I 0.000057 E
CAPROLACTAM 105602 0.5 I
CARBARYL
63252 0.1 I


CARBON DISULFIDE
75150 0.1 I 0.2 I y
CARBON TETRACHLORIDE 56235 0.0007 I 0.05 M y
CARBOSULFAN
55285148 0.01 I


CHLORAL HYDRATE
302170 0.1 I


CHLORANIL 118752
CHLORDANE
57749 0.0005 I 0.0002 I
CHLORINE DIOXIDE
10049044 0.03 I 0.000057 I y
CHLOROACETIC ACID 79118 0.002 H
4-CHLOROANILINE
106478 0.004 I


CHLOROBENZENE
108907 0.02 I 0.014 P y
2-CHLORO-1,3-BUTADIENE 126998 0.02 A 0.002 H y
1-CHLORO-1,1-DIFLUOROETHANE
75683
14 I y
CHLORODIFLUOROMETHANE
75456
14 I y
CHLOROETHANE 75003 0.4 E 2.9 I y
CHLOROFORM
67663 0.01 I 0.014 E y
CHLOROMETHANE
74873
0.026 I y
4-CHLORO-2-METHYLANILINE 95692
BETA-CHLORONAPHTHALENE
91587 0.08 I

y
2-CHLOROPHENOL
95578 0.005 I

y
2-CHLOROPROPANE 75296 0.029 H y
O-CHLOROTOLUENE
95498 0.02 I

y
P-CHLOROTOLUENE
106434 0.07 P

y
CHLORPYRIFOS 2921882 0.003 I
CHLORPYRIFOS-METHYL
5598130 0.01 H


CHROMIUM III
16065831 1.5 I


CHROMIUM VI 18540299 0.003 I 0.00003 I
COKE OVEN EMISSIONS (COAL TAR) m 8007452



COPPER
7440508 0.04 H


CUMENE 98828 0.1 I 0.11 I y
CYANIDE (FREE)
57125 0.02 I


CALCIUM CYANIDE
592018 0.04 I


COPPER CYANIDE 544923 0.005 I
CYANOGEN
460195 0.04 I

y
HYDROGEN CYANIDE
74908 0.02 I 0.00086 I y
POTASSIUM CYANIDE 151508 0.05 I
POTASSIUM SILVER CYANIDE
506616 0.2 I


SILVER CYANIDE
506649 0.1 I


SODIUM CYANIDE 143339 0.04 I
THIOCYANATES
0.0002 P


ZINC CYANIDE
557211 0.05 I


CYCLOHEXANE 110827 1.7 I y
CYCLOHEXANONE
108941 5 I


CYHALOTHRIN/KARATE
68085858 0.005 I


CYPERMETHRIN 52315078 0.01 I
DACTHAL
1861321 0.01 I


DALAPON
75990 0.03 I


DDD 72548
DDE
72559



DDT
50293 0.0005 I


DIAZINON 333415 0.0009 H
**DIBENZOFURAN
132649 0.001 P


1,4-DIBROMOBENZENE
106376 0.01 I


DIBROMOCHLOROMETHANE 124481 0.02 I y
1,2-DIBROMO-3-CHLOROPROPANE m 96128 0.0002 P 0.000057 I y
1,2-DIBROMOETHANE
106934 0.009 I 0.0026 I y
DIBUTYLPHTHALATE 84742 0.1 I
DICAMBA
1918009 0.03 I


1,2-DICHLOROBENZENE
95501 0.09 I 0.04 H y
1,3-DICHLOROBENZENE 541731 0.003 E y
1,4-DICHLOROBENZENE
106467 0.03 E 0.229 I y
3,3'-DICHLOROBENZIDINE
91941



DICHLORODIFLUOROMETHANE 75718 0.2 I 0.05 A y
1,1-DICHLOROETHANE
75343 0.2 P 0.14 A y
1,2-DICHLOROETHANE
107062
0.7 M y
1,1-DICHLOROETHENE 75354 0.05 I 0.06 I y
CIS-1,2-DICHLOROETHENE
156592 0.01 P

y
**TRANS-1,2-DICHLOROETHENE
156605 0.02 I 0.017 P y
TOTAL 1,2-DICHLOROETHENE 540590 0.009 H y
2,4-DICHLOROPHENOL
120832 0.003 I


2,4-D
94757 0.01 I


4-(2,4-DICHLOROPHENOXY)BUTYRIC ACID 94826 0.008 I
1,2-DICHLOROPROPANE
78875
0.00114 I y
1,3-DICHLOROPROPANE
142289 0.02 P

y
2,3-DICHLOROPROPANOL 616239 0.003 I
1,3-DICHLOROPROPENE
542756 0.03 I 0.00571 I y
DICHLORVOS
62737 0.0005 I 0.000143 I
DIELDRIN 60571 0.00005 I
DIESEL EMISSIONS

0.0014 I
DIETHYLPHTHALATE
84662 0.8 I

DI(2-ETHYLHEXYL)ADIPATE 103231 0.6 I
DIETHYLSTILBESTROL
56531


DIFENZOQUAT (AVENGE)
43222486 0.08 I

1,1-DIFLUOROETHANE 75376 11 I y
DIISOPROPYL METHYLPHOSPHONATE (DIMP)
1445756 0.08 I

3,3'-DIMETHOXYBENZIDINE
119904


N,N-DIMETHYLANILINE 121697 0.002 I
2,4-DIMETHYLPHENOL
105679 0.02 I

2,6-DIMETHYLPHENOL
576261 0.0006 I

3,4-DIMETHYLPHENOL 95658 0.001 I
1,2-DINITROBENZENE
528290 0.0001 P

1,3-DINITROBENZENE
99650 0.0001 I

1,4-DINITROBENZENE 100254 0.0001 P
4,6-DINITRO-O-CYCLOHEXYL PHENOL
131895 0.002 I

2,4-DINITROPHENOL
51285 0.002 I

DINITROTOLUENE MIX
2,4-DINITROTOLUENE
121142 0.002 I

2,6-DINITROTOLUENE
606202 0.001 P

DINOSEB 88857 0.001 I
1,4-DIOXANE
123911


DIPHENYLAMINE
122394 0.025 I

1,2-DIPHENYLHYDRAZINE 122667
DIQUAT
85007 0.0022 I

DISULFOTON
298044 0.00004 I

1,4-DITHIANE 505293 0.01 I
DIURON
330541 0.002 I

ENDOSULFAN
115297 0.006 I

ENDRIN 72208 0.0003 I
EPICHLOROHYDRIN
106898 0.006 P 0.000286 I y
ETHION
563122 0.0005 I

ETHYL ACETATE 141786 0.9 I y
ETHYLBENZENE
100414 0.1 I 0.29 I y
ETHYLENE GLYCOL
107211 2 I

ETHYLENE GLYCOL, MONOBUTYL ETHER 111762 0.5 I 3.7 I
ETHYLENE OXIDE
75218


y
ETHYL ETHER
60297 0.2 I

y
FENAMIPHOS 22224926 0.00025 I
FLUOMETURON
2164172 0.013 I

FLUORINE
7782414 0.06 I

FOMESAFEN 72178020
FONOFOS
944229 0.002 I

FORMALDEHYDE
50000 0.2 I

FURAN 110009 0.001 I y
FURFURAL
98011 0.003 I 0.01 A
GLYPHOSATE
1071836 0.1 I

HEPTACHLOR 76448 0.0005 I
HEPTACHLOR EPOXIDE
1024573 0.000013 I

HEXABROMOBENZENE
87821 0.002 I

HEXACHLOROBENZENE 118741 0.0008 I
HEXACHLOROBUTADIENE
87683 0.0002 H

ALPHA-HCH
319846


BETA-HCH 319857
GAMMA-HCH (LINDANE)
58899 0.0003 I

TECHNICAL HCH
608731


HEXACHLOROCYCLOPENTADIENE 77474 0.006 I 0.000057 I
HEXACHLORODIBENZODIOXIN MIX
19408743


HEXACHLOROETHANE
67721 0.001 I

HEXACHLOROPHENE 70304 0.0003 I
1,6-HEXAMETHYLENE DIISOCYANATE
822060
0.0000029 I
HEXANE
110543
0.2 I y
HMX 2691410 0.05 I
HYDRAZINE
302012


HYDROGEN CHLORIDE
7647010
0.0057 I
HYDROGEN SULFIDE 7783064 0.003 I 0.00057 I
**IRON
7439896 0.7 P

ISOBUTANOL
78831 0.3 I

y
ISOPHORONE 78591 0.2 I
TETRAETHYLLEAD
78002 1E-07 I

KEPONE
143500 0.0005 M

LITHIUM 7439932 0.02 E
MALATHION
121755 0.02 I

MALEIC ANHYDRIDE
108316 0.1 I

MANGANESE-NONFOOD 7439965 0.02 I 0.0000143 I
MANGANESE-FOOD
7439965 0.14 I 0.0000143 I
MEPHOSFOLAN
950107 0.00009 H

MEPIQUAT CHLORIDE 24307264 0.03 I
MERCURIC CHLORIDE
7487947 0.0003 I

MERCURY (elemental)
7439976
0.000086 I
METHYLMERCURY 22967926 0.0001 I
METHANOL
67561 0.5 I

METHIDATHION
950378 0.001 I

METHOXYCHLOR 72435 0.005 I
METHYL ACETATE
79209 1 H

y
METHYL ACRYLATE
96333 0.03 A

y
2-METHYLANILINE 95534
4-(2-METHYL-4-CHLOROPHENOXY) BUTYRIC ACID
94815 0.01 I

2-METHYL-4-CHLOROPHENOXYACETIC ACID (MCPA)
94746 0.0005 I

2-(2-METHYL-4-CHLOROPHENOXY)PROPIONIC ACID (MCPP) 93652 0.001 I
METHYLCYCLOHEXANE
108872
0.86 H y
METHYLENE BROMIDE
74953 0.01 A

y
METHYLENE CHLORIDE 75092 0.06 I 0.3 M y
4,4'-METHYLENE BIS(2-CHLOROANILINE) m 101144 0.002 P

4,4'-METHYLENE BIS(N,N'-DIMETHYL)ANILINE
101611


4,4'-METHYLENEDIPHENYL ISOCYANATE 101688 0.00017 I
METHYL ETHYL KETONE (2-BUTANONE)
78933 0.6 I 1.4 I y
METHYL ISOBUTYL KETONE (4-METHYL-2-PENTANONE)
108101
0.86 I y
METHYL METHACRYLATE 80626 1.4 I 0.2 I y
METHYL PARATHION
298000 0.00025 I

2-METHYLPHENOL
95487 0.05 I

3-METHYLPHENOL 108394 0.05 I
4-METHYLPHENOL
106445 0.005 H

METHYLSTYRENE MIX
25013154 0.006 A 0.01 A y
ALPHA-METHYLSTYRENE 98839 0.07 A y
METHYL TERT-BUTYL ETHER
1634044
0.857 I y
METOLACHLOR (DUAL)
51218452 0.15 I

MIREX 2385855 0.0002 I
MOLYBDENUM
7439987 0.005 I

MONOCHLORAMINE
10599903 0.1 I 0.1 H
NALED 300765 0.002 I
NICKEL REFINERY DUST




NICKEL
7440020 0.02 I


NITRATE 14797558 1.6 I
NITRITE
14797650 0.1 I


NITROBENZENE
98953 0.0005 I 0.0006 A y
**NITROGLYCERIN 55630 0.0001 P
2-NITROPROPANE
79469
0.0057 I y
N-NITROSO-DI-N-BUTYLAMINE
924163


y
N-NITROSODIETHANOLAMINE 1116547
**N-NITROSODIETHYLAMINE m 55185



**N-NITROSODIMETHYLAMINE m 62759



N-NITROSODIPHENYLAMINE 86306
N-NITROSODIPROPYLAMINE
621647



N-NITROSO-N-METHYLETHYLAMINE
10595956



N-NITROSOPYRROLIDINE 930552
O-NITROTOLUENE
88722 0.01 H

y
NUSTAR
85509199 0.0007 I


ORYZALIN 19044883 0.05 I
OXADIAZON
19666309 0.005 I


OXAMYL
23135220 0.025 I


OXYFLUORFEN 42874033 0.003 I
PARAQUAT DICHLORIDE
1910425 0.0045 I


PARATHION
56382 0.006 H


PENTACHLOROBENZENE 608935 0.0008 I
PENTACHLORONITROBENZENE
82688 0.003 I


PENTACHLOROPHENOL
87865 0.03 I


PERCHLORATE 0.0007 I
PERMETHRIN
52645531 0.05 I


PHENOL
108952 0.3 I


M-PHENYLENEDIAMINE 108452 0.006 I
O-PHENYLENEDIAMINE
95545



P-PHENYLENEDIAMINE
106503 0.19 H


PHOSGENE 75445 0.000086 I y
PHOSPHINE
7803512 0.0003 I 0.000086 I
PHOSPHORIC ACID
7664382
0.0029 I
PHOSPHORUS (WHITE) 7723140 0.00002 I
PHTHALIC ANHYDRIDE
85449 2 I 0.0343 H
POLYBROMINATED BIPHENYLS
0.000007 H


POLYCHLORINATED BIPHENYLS 1336363
AROCLOR-1016
12674112 0.00007 I


AROCLOR-1221
11104282



AROCLOR-1232 11141165
AROCLOR-1242
53469219



AROCLOR-1248
12672296



AROCLOR-1254 11097691 0.00002 I
AROCLOR-1260
11096825



POLYNUCLEAR AROMATIC HYDROCARBONS:




ACENAPHTHENE 83329 0.06 I y
ANTHRACENE
120127 0.3 I

y
BENZ[A]ANTHRACENE m 56553



BENZO[B]FLUORANTHENE m 205992
BENZO[K]FLUORANTHENE m 207089



BENZO[A]PYRENE m 50328



CARBAZOLE 86748
CHRYSENE m 218019



DIBENZ[A,H]ANTHRACENE m 53703



FLUORANTHENE 206440 0.04 I
FLUORENE
86737 0.04 I

y
INDENO[1,2,3-C,D]PYRENE m 193395



2-METHYLNAPHTHALENE 91576 0.004 I y
NAPHTHALENE
91203 0.02 I 0.0009 I y
PYRENE
129000 0.03 I

y
PROMETON 1610180 0.015 I
PROMETRYN
7287196 0.004 I


PROPACHLOR
1918167 0.013 I


PROPARGITE 2312358 0.02 I
PROPYLENE GLYCOL, MONOETHYL ETHER
52125538 0.7 H


PROPYLENE GLYCOL, MONOMETHYL ETHER
107982 0.7 H 0.57 I
PURSUIT 81335775 0.25 I
PYRIDINE
110861 0.001 I


QUINOLINE
91225



RDX 121824 0.003 I
RESMETHRIN
10453868 0.03 I


ROTENONE
83794 0.004 I


SELENIUM 7782492 0.005 I
SILVER
7440224 0.005 I


SIMAZINE
122349 0.005 I


SODIUM DIETHYLDITHIOCARBAMATE 148185 0.03 I
STRONTIUM, STABLE
7440246 0.6 I


STRYCHNINE
57249 0.0003 I


STYRENE 100425 0.2 I 0.286 I y
2,3,7,8-TETRACHLORODIBENZODIOXIN
1746016



1,2,4,5-TETRACHLOROBENZENE
95943 0.0003 I


1,1,1,2-TETRACHLOROETHANE 630206 0.03 I y
**1,1,2,2-TETRACHLOROETHANE
79345


y
TETRACHLOROETHENE
127184 0.01 I 0.08 M y
2,3,4,6-TETRACHLOROPHENOL 58902 0.03 I
P,A,A,A-TETRACHLOROTOLUENE
5216251



1,1,1,2-TETRAFLUOROETHANE
811972
22.9 I y
TETRAHYDROFURAN 109999 0.2 E 0.086 E
TETRYL
479458 0.004 P


THALLIUM
7440280 0.00007 O


THALLIUM ACETATE 563688 0.00009 I
THALLIUM CARBONATE
6533739 0.00008 I


THALLIUM CHLORIDE
7791120 0.00008 I


THALLIUM NITRATE 10102451 0.00009 I
THALLIUM SULFATE (2:1)
7446186 0.00008 I


THIOBENCARB
28249776 0.01 I


TIN 7440315 0.6 H
TOLUENE
108883 0.08 I 1.4 I y
TOLUENE-2,4-DIAMINE
95807



TOLUENE-2,5-DIAMINE 95705 0.6 H
TOLUENE-2,6-DIAMINE
823405 0.03 P


P-TOLUIDINE
106490



TOXAPHENE 8001352
1,2,4-TRIBROMOBENZENE
615543 0.005 I


TRIBUTYLTIN OXIDE
56359 0.0003 I


2,4,6-TRICHLOROANILINE 634935
1,2,4-TRICHLOROBENZENE
120821 0.01 I

y
1,1,1-TRICHLOROETHANE
71556 0.28 E

y
1,1,2-TRICHLOROETHANE 79005 0.004 I y
TRICHLOROETHENE
79016 0.0003 E 0.01 E y
TRICHLOROFLUOROMETHANE
75694 0.3 I 0.2 A y
2,4,5-TRICHLOROPHENOL 95954 0.1 I
2,4,6-TRICHLOROPHENOL
88062



2,4,5-T
93765 0.01 I


2-(2,4,5-TRICHLOROPHENOXY)PROPIONIC ACID 93721 0.008 I
1,1,2-TRICHLOROPROPANE
598776 0.005 I

y
1,2,3-TRICHLOROPROPANE
96184 0.006 I 0.0014 E y
1,1,2-TRICHLORO-1,2,2-TRIFLUOROETHANE 76131 30 I 8.6 H y
1,3,5-TRINITROBENZENE
99354 0.03 I


2,4,6-TRINITROTOLUENE
118967 0.0005 I


URANIUM (SOLUBLE SALTS; from IRIS) 7440611 0.003 I 0.000086 M
URANIUM (SOLUBLE SALTS; provisional)
7440611 0.0002 E 0.000086 M
VANADIUM
7440622 0.001 E


VINCLOZOLIN 50471448 0.025 I
VINYL ACETATE
108054 1 H 0.0571 I y
VINYL CHLORIDE inc earlylife(see cover memos)
75014 0.003 I 0.028 I y
VINYL CHLORIDE: adult (see cover memos) 75014 0.003 I 0.028 I y
WARFARIN
81812 0.0003 I


XYLENES
1330207 0.2 I 0.03 I y
ZINC 7440666 0.3 I
ZINEB
12122677 0.05 I




Table Sources:
I = IRIS
H = HEAST
A = HEAST Alternate
M = ATSDR MRL (chronic)
E = EPA-NCEA provisional value
O = other
P = EPA provisional peer-reviewed value
m = Default ADAFs applied, carcinogenic via mutagenic mode of action
Adapted from US EPA region III (2007); http://www.epa.gov/reg3hwmd/risk/human/index.htm 

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